Similar pattern was observed in the analysis of 173 NSCLC tumors by Lee et al. (36) PTEN inactivation decreases sensitivity of EGFR-mutant lung tumors to EGFR through partial uncoupling of mutant EGFR from downstream signaling leading to EGFR activation and through activation of AKT (37). The gene discussed is AKT1; the disease is non-small cell lung carcinoma.