MYB and neoplasm: Firstly, a direct inhibition of tumor growth, via tumor cell binding, uptake, and inhibition of c-myb proto-oncogene expression; secondly, an indirect CpG-dependent immune stimulation, whose function was lost as the result of using clodronate-driven macrophage depletion in nude mice (Figure 2C) and B and NK cells depletion in SCID-bg mice (Figure 2D) (17).