FLT3 and acute promyelocytic leukemia: Despite several reports of association between FLT3-ITD and other characteristics of APL, including elevated white blood cell (WBC) counts, hypogranular variant morphology (M3v), and the short (bcr-3) isoform of PML-RARα, the prognostic significance of FLT3 mutations still needs to be firmly established [6].