FLT3 and Increased total leukocyte count: Other studies have shown that FLT3-ITD mutations are able to cooperate with CEBPA mutations to induce acute leukemia in a mouse model; particularly, it was shown that coexpression of FLT3-ITD together with a C-terminal CEBPA mutant considerably shortened the latency period of leukemia development and markedly increased leukocytosis [53].