FLT3 and leukemia: The analysis of the mechanisms of cooperation between FLT3-ITD and CEBPA mutants at the level of stem/progenitor cells showed that hematopoietic stem cells and hematopoietic progenitor cell expansion elicited by CEBPA mutations is amplified by FLT3-ITD; furthermore, it was shown that in this mouse leukemia model cells with leukemia initiating capacity reside at the level of the committed myeloid progenitor compartment [54].