In fact, in a study involving 82 patients with myelodysplasia who developed over time acute myeloid leukemia, 6% of patients had FLT3-ITD mutations at the time of diagnosis of myelodysplasia, and an additional 10% of patients acquired these mutations during disease progression to acute leukemia [26]. The gene discussed is FLT3; the disease is Myelodysplasia.