VWF and von Willebrand disease (hereditary or acquired): In the last years, some diagnostic criteria have been proposed to tentatively standardize VWD diagnosis.2 A “definite” diagnosis of type 1 VWD requires the presence of significant mucocutaneous bleeding (this latter being presence of at least two symptoms or of one requiring blood transfusion), reduced VWF levels (>2SD below the mean) and at least another family member with reduced VWF.