During the last two decades, more than 20 proteins have been identified that interact with VWF, several of them being involved in cellular signaling processes.32 Consequently, VWF has been linked to other (patho)physological processes than haemostasis as well, including angiodysplasia, tumor metastasis and smooth muscle cell proliferation (Figure 2; for recent reviews on these topics see references 32,134,135). Here, VWF is linked to neoplasm.