However, the lifespans of Sod2+/− mice were identical to those of WT mice and biomarkers of aging, such as cataract formation, immune response, and formation of glycoxidation products carboxymethyl lysine and pentosidine in skin collagen changed with age to the same extent in both WT and Sod2+/− mice [30], indicating that life-long reduction of Mn-SOD activity leads to increased levels of oxidative damage to DNA and increased cancer incidence but does not appear to affect aging. The gene discussed is SOD2; the disease is cancer.