The investigators also suggested that NRF2 haplotype alleles were associated with 2 years earlier age of Alzheimer's disease (AD) onset, 4 years earlier age of posterior subcapsular cataract surgery, and 4 years later age of cortical cataract surgery while they were not significantly related to AD or age-related cataract risk [45]. The gene discussed is NFE2L2; the disease is Alzheimer disease.