Importantly, effects of interaction between prenatal stress and NRF2 SNPs on descendant pulmonary health were investigated by the Avalon Longitudinal Study in the UK: maternal smoking during pregnancy was not associated with lung function change determined by maximum mild expiratory flow (FEF25–75) or with asthma incidence in school-aged children, and this relation was not modified by NRF2 SNP genotypes [42]. The gene discussed is NFE2L2; the disease is asthma.