NFE2L2 and breast carcinoma: In a study of a Finish population (Kuopio Breast Cancer Project, n = 452 patients, 370 controls), the −178A/A homozygous genotype (OR 4.656; CI = 1.35–16.06) and 3′ flanking rs2706110 (T/T; OR 2.079, CI 1.18–3.68) genotype were associated with increased risk of breast cancer, while the 5′ flanking −3,306T/T homozygous allele was significantly associated with lower survival (frequency = 71/219, OR 1.687, CI 1.105–2.75) [27], suggesting that NRF2 genetic polymorphisms affect susceptibility and outcome of the patients.