Thus lepromatous leprosy was associated with IL-4, IL-5 and absence of IFN-γ in antigen stimulated PBMC cultures as well as skin lesions indicating Th2 polarization and tuberculoid leprosy in contrast was reported to show Th1 responses where IFN-γ, IL-2 were the predominant cytokines [6], [7], [8] . The gene discussed is IFNG; the disease is tuberculoid leprosy.