IL6 and central nervous system cancer: Figure 7b and 7c show that there was a IL6 dose-dependent increase in oHSV replication, although at very high doses oHSV replication returned to baseline. Figure 7B shows fluorescent plaques from GFP-expressing virus after infection of OG02 glioma cells that grow as spheroids (clumps) rather than monolayers. The 3 dimensional nature of the spheroids on a dish tends to render the visualized GFP signal a bit unfocused. There was also an increase in oHSV-mediated cytotoxicity up to a dose of 10ng/ml of IL-6 (Figure 7d).