CXCR4 and gastric cancer: As shown in Table 3, Lauren classification (P=0.025), T classification (P=0.002), N classification (P=0.001), distant metastasis (P<0.001), TNM stage (P<0.001), and CXCR4 expression (P<0.001) were statistically significant risk factors affecting overall survival of patients with gastric cancer.