Kwak et al. investigated the CXCR4 expression immumohistochemically in more than three hundred gastric cancer patients, they concluded that there were no significant clinical implications of CXCR4 expression in gastric cancer except for tumor histology, and the expression of the chemokine receptor CXCR4 was found to be high in differentiated and intestinal-type gastric cancers [27]. This evidence concerns the gene CXCR4 and neoplasm.