In addition, CXCR7 is also a receptor for CXCL12 that binds this chemokine with greater affinity [28], the clinical and prognostic implications of CXCL12/CXCR4/CXCR7 axis in patients with gastric cancer remain to be elucidated in future. The gene discussed is ACKR3; the disease is gastric cancer.