Anyway, our findings that the strongest cellular cytotoxic response of lymphocytes occurred in the TIM-3 positive subpopulation of different lymphocytes subsets underlines the fact, that the involvement of the immunoregulatory receptor TIM-3 in the pathogenesis of the systemic inflammatory response observed in early-onset preeclampsia is incontestable and represents theoretically a site of therapeutic intervention for immune suppression. Here, HAVCR2 is linked to preeclampsia.