At the same time, a literature synthesis performed by Uldrick et al. (2012) shows that in HHV-8-induced KS, the viral gene products, such as viral G protein-coupled receptor (vGPCR), viral interleukin-6, and latency-associated nuclear antigen (LANA), upregulate VEGF production [20] from the genetically modified PMCs [37], [45] but also promote cell proliferation, with vGPCR being sufficient to induce the angiogenic phenotype [42]. This evidence concerns the gene VEGFA and Kaposi's sarcoma.