No significant difference in baseline demographics, smoking behaviors, baseline plasma cotinine levels, urinary TNE, and levels of nicotine dependence were observed between UGT2B17 or UGT2B10 genotype groups (Table 1), indicating that neither the UGT2B17 gene deletion nor the UGT2B10*2 were associated with the levels of tobacco consumption or nicotine dependence. The gene discussed is UGT2B17; the disease is nicotine dependence.