Although miRNA-205 has been shown to inhibit mRNA and protein expression of Lyn, c-Src, and c-Yes in A498 cells resulting in G0/G1 cell cycle arrest and apoptosis [41], and Lyn specifically reduced expression of miRNA-181b that represses the anti-apoptotic protein Mcl1 [42], we did not detect a change in miRNA expression (≥ or ≤1.5-fold) in the U87-CA-Lyn or U87-DN-Lyn cells as compared to U87-LV cells using the Human Cancer miRNA PCR Array (MAH-102A, Qiagen) (WM Liu and CL Gladson, unpublished data). The gene discussed is YES1; the disease is cancer.