Figure 2 summarizes the interplay between adiponectin and ADM based on findings from this study and previous studies. Adiponectin and ADM could regulate each other in 3 ways: 1. The adiponectin SNP rs182052 could interact with ADM SNP since we previously showed that ADM SNPs could influence plasma ADM level [7]; 2. ADM could directly increase adiponectin gene expression and secretion in vitro [13]; 3. In type 2 diabetes, plasma adiponectin level tends to be lower [36], while plasma ADM level tends to be higher [6]. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.