We first performed a reporter gene assay to determine the effect of these four SNPs on transcriptional activity using two human pancreatic cancer cell lines, Su86 and HupT3, both of which express FKBP5. The regions containing the rs73746499 and rs148128369 SNPs did not show a significant change in luciferase activity (data not shown). This evidence concerns the gene FKBP5 and familial pancreatic carcinoma.