MMP2 and lung cancer: In the present study, we provide evidence that miR-29c expression in high-metastatic 95D cell lines was downregulated when compared to miR-29c expression in paired low-metastatic 95C cell lines, ectopic expression and siRNA knockdown of miR-29c confirmed it directly targeted 3′-UTR of integrin β1 and MMP2 mRNA and downregulated integrin β1 and MMP2 protein expression to suppress lung cancer cell adhesion to ECM and metastasis in vitro and in vivo.