Previous study found that miR-29c down-regulated protein expression of several extracellular matrix components including multiple collagens and laminin γ1 in nasopharyngeal carcinoma, and miR-29c may also directly target DNMT3A and DNMT3B in lung cancer (Fabbri, et al., 2007; Sengupta, et al., 2008). The gene discussed is DNMT3B; the disease is lung cancer.