However, the fact that the p120-catenin membrane staining was significantly decreased in advanced carcinomas and that the p120-catenin cytoplasmic staining was limited and did not associate with E-cadherin staining emphasizes again the impact of loss of p120-catenin expression, but not the subcellular localization and the isoform shift, on the carcinoma progression and loss of E-cadherin expression. This evidence concerns the gene CDH1 and carcinoma.