FGFR1 and breast neoplasm: In other diseases over-expression of FGF2, the ligand for FGF-R1, was shown to enhance apoptosis in MCF7 breast tumor cells exposed to chemotherapy such as cisplatin or 5-fluorouracil and to sensitize NIH 3T3 cells to apoptosis induced by cisplatin [31], [32], but this has not yet been proven to be the case for metastatic melanoma.