Since sorafenib does not improve OS, PFS or response rate when added to carboplatin and paclitaxel, and seeing that carboplatin and paclitaxel use for melanoma has increased in recent years, particularly for B-Raf wild-type melanomas and patients who are not candidates for immune therapy, these biomarkers should be validated in additional cohorts, and their role as predictive versus prognostic biomarkers should be clarified in untreated patients. The gene discussed is BRAF; the disease is melanoma.