MAPK8 and colon carcinoma: The human colon carcinoma cell line caco-2 was commonly used in vitro to study the molecular mechanisms underlying differentiation, biosynthesis and drug absorption of intestinal epithelial cells, it may also be a suitable model to investigate colonic inflammatory immune response including pro-inflammatory cytokines release [48], intracellular activation of JNK and p38 MAPK signaling [49] as well as NF-κB translocation [50].