Among these factors, the overproduction of pro-inflammatory mediators, such as TNF-a, IL-1, IL-6, and IL-8, the presence of highly activated inflammatory cells such as macrophages neutrophils, and monocytes, as well as an excessive production of reactive oxygen species (ROS) appear to play major roles in the pathogenesis of IBD [2-7]. The gene discussed is TNF; the disease is inflammatory bowel disease.