We investigated the dynamics of monocyte subsets in blood of acute patients with ischemic stroke, and found that the percentages of CD14highCD16- classical monocytes (classical Mo) and CD14highCD16+ intermediate monocytes (intermediate Mo) were increased, whereas that of CD14 dimCD16high non-classical monocytes (non-classical Mo) was decreased after stroke. The gene discussed is CD14; the disease is Stroke.