RB1 and non-small cell lung carcinoma: In this study, we found that the expression of WT1 gene and protein in NSCLC specimens was markedly up-regulated compared with adjacent tissues; WT1 promoted proliferation of NSCLC cells in vitro and vivo, and WT1 expression affected the level of Cyclin D1 and p-pRb which accelerated cell proliferation in NSCLC cells and clinical specimens.