Buechner J. et al revealed that mir-92b expression was downregulated in MYCN ((v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)) repressed SK-N-BE cells [47], In addition, MYCN-regulated mir-92b that could target the 3, UTR sequence of DKK3 (Dickkopf-3), which functions as a tumor suppressor in a range of tumors [48]–[50]. This evidence concerns the gene MYCN and neuroblastoma.