Our data support the hypotheses that: 1) a segregation of CC genotype occurs in subjects who spontaneously cleared HCV infection, 2) CC genotype could play a protective role against the development of chronic HCV infection, and 3) IL28B SNP may have a primary importance in establishing the prognosis of patients affected by acute hepatitis C [15], [19]. This evidence concerns the gene IFNL3 and hepatitis C virus infection.