Figure 2, shows the unadjusted association of CYP11B2 −344CC genotype with AF status (prevalence difference of 0.54, 95% CI 0.20 to 0.88, p = 0.003) on the left. Figure 2 on the right displays marginal standardization, which is the average prevalence difference between genotype groups adjusted for age, sex, body size, creatinine clearance, systemic hypertension, diabetes, coronary artery disease, left atrial size, mitral regurgitation, and European ancestry. The CYP11B2 CC genotype was associated with an adjusted AF prevalence difference of 40 percentage points (95% CI 9 to 67). The gene discussed is CYP11B2; the disease is mitral valve insufficiency.