GNRH1 and central precocious puberty: Despite the number of reported data and analyses concerning idiopathic CPP in girls, major questions remain, including 1) the differential diagnosis between CPP and PT, including the interpretation of hormonal test results that support the diagnosis, 2) the respective role of genetic and environmental factors, and 3) the evolution of estrogen secretion and indications of GnRH analog treatment [16], [17].