Recently, It was reported Trk inhibitor K252a inhibited cell growth and induced apoptotic cell death in uterine leiomyosarcoma [47].Therefore, further studies are needed to explore the development of small-molecule compounds that act as TrkB antagonists, or monoclonal antibodies against either BDNF or TrkB, as promising novel therapies for the treatment of endometrial carcinoma. This evidence concerns the gene BDNF and endometrial carcinoma.