Previous studies have demonstrated a key role for BDNF-TrkB signaling in modulating the response to cytotoxic agents, and modulation of TrkB expression enhanced the sensitivity of cells to cis-Diamminedichloroplatinum Cisplatin (CDDP) in head and neck squamous cell carcinoma [16]. The gene discussed is BDNF; the disease is head and neck squamous cell carcinoma.