Though there was a trend towards increased tumor volume of dissemination in the IshikawaTrkB group, no significant differences between the IshikawaTrkB group and the IshikawaEV group were observed (p>0.05, NS, Figures 7C and 7D, right), suggesting that the extent of the in vivo effect of TrkB may be cell-dependent. This evidence concerns the gene NTRK2 and neoplasm.