NTRK2 and endometrial carcinoma: Recently, It was reported Trk inhibitor K252a inhibited cell growth and induced apoptotic cell death in uterine leiomyosarcoma [47].Therefore, further studies are needed to explore the development of small-molecule compounds that act as TrkB antagonists, or monoclonal antibodies against either BDNF or TrkB, as promising novel therapies for the treatment of endometrial carcinoma.