However, because CCR5-Δ32/Δ32 mutation associates with strong protection against HIV infection, an alternative explanation could be that HCV-positive survivors in populations under selective pressure of HIV infection (e.g. hemophiliacs), the overrepresentation of CCR5-Δ32/Δ32 genotype could represent those who resisted HIV infection [5]. The gene discussed is CCR5; the disease is HIV infectious disease.