Moreover, androgen binding by SHBG can also stimulate cAMP and PKA in the prostate cancer cell line LNCaP [16], [20]and the SHBG receptor (SHBG-R) could connect to the G protein complex which may conversely bind androgens or influence the activity of a membrane androgen-binding protein indirectly [40]. Here, SHBG is linked to Familial prostate cancer.