26 SNPs were associated with the expression levels of CEACAM21 and LOC100505495, and 3 others SNPs were associated with CEACAM21 and CEACAM4. The eQTLs on 19q13 were mainly located in two discrete foci one distal and one proximal to the COPD susceptibility locus RAB4B/EGLN2/MIA/CYP2A6 (Figure 8). The gene discussed is CEACAM21; the disease is chronic obstructive pulmonary disease.