These five SNPs did not significantly associated with the expression of genes at that locus, but a trend was observed with FAM13A. In fact, three of those five polymorphisms, in complete LD with each other (rs2045517, rs2869967, rs2869966) and in modest LD (r2 = 0.53–0.69) with COPD SNPs were nominally associated with the expression levels of FAM13A (p = 4.1×10−5). Here, FAM13A is linked to chronic obstructive pulmonary disease.