Gene ontology classes of the predicted cellular targets of HPV16-miR-H1-1 suggest important roles in host cell interactions of HPV 16, such as the cell cycle process (CUL3, CYP26B1, MAP3K11, PBRM1, SMC1A), especially the M phase (CYP26B1, PBRM1, SMC1A), which is important for viral infection [5]. Here, CUL3 is linked to viral infectious disease.