Importantly, target genes involved in epithelium development (RGMA, SHANK3, PAX6, PFN1, WNT4) and cancer (CBL, CYCS, FGF7, IGF1R, PTEN, PIK3CD, WNT4) address to a further role in the onset of epithelial abnormalities and oncogenesis. The gene discussed is RGMA; the disease is cancer.