Elevated IFN-α (muscle), IFN-β (brainstem, spinal cord, and muscle), and IFN-γ (brainstem and muscle) responding to the innate immunity against virus infection were downregulated in transgenic mice that received N3 after infection in contrast to non-treated or isotype antibody-treated mice (Fig. 8). Here, IFNB1 is linked to viral infectious disease.