Interestingly, this heightened migratory behavior was susceptible to inhibition of autotaxin function by S32826 treatment as pleural and peritoneal mesothelioma cell migration was severely inhibited (68% reduction in MSTO displacement, 87% reduction in ROB displacement), reducing motility to that of parietal cells (Figure 7C–D; Figure S1). Here, ENPP2 is linked to peritoneal mesothelioma.