For example, metformin which activates AMP-activated protein kinase (AMPK) and is one of the most common drugs used to treat type 2 diabetes has been shown to inhibit T lymphocyte antigen specific recall responses and the production of Th1 and Th17 cytokines, while upregulating IL-10 secretion in mouse splenocytes [45]. The gene discussed is IL10; the disease is type 2 diabetes mellitus.