Because the basilar membrane in the inner ear regulates fluid and ion transport between the endolymph and perilymph [13], mutated components of the basilar membrane could lead to disturbance of ionic homeostasis and result in hearing loss, as shown by laminin [5] in nonsyndromic deafness and an altered expression of collagen IV chains in Alport’s syndrome [6]. This evidence concerns the gene LAMB2 and Alport syndrome.