In summary, this meta-analysis showed that the CA27 allele of the IL-10.G microsatellites, the IL-10 −1082G/A polymorphism and its associated haplotype of GCC are associated with SLE susceptibility among Caucasians and the CA21 allele of the IL-10.G microsatellites, the IL-10 −1082G/A and −592 C/A polymorphisms and their associated haplotype of GCC may be associated with SLE susceptibility among Asians. This evidence concerns the gene IL10 and systemic lupus erythematosus.