CNVs in FCGR3B, CCL3L1, and C4 for systemic lupus erythematosus (SLE) [2], [3], [4], [5], DEFB4 for Crohn disease [6], alpha-defensin for Psoriasis [7], CCL3L1 for susceptibility to HIV-1 infection [8], the RHD gene for the Rh-negative blood group [9], and the alpha-globin gene for alpha-thalassemia [10], have been reported. This evidence concerns the gene C4A and systemic lupus erythematosus.