LRRK2 and Parkinson disease: The putamen ASI for PD cases with GBA mutations (median 0.18 [0.08–0.33], p<0.001) and LRRK2 (median 0.52 [0.13–0.5], p<0.001) differed significantly from the control value (median 0.89 [0.82–0.96])(Figure 1b).