From our analysis, we also suggested a minimal combination of proteins, SMO, HFU, ULK3, RAS and ERK12, the expressions of which needed to be inhibited so as to control the effect of mutated hedgehog signaling pathway in pancreatic cancer by suppressing the activity of different proteins responsible for uncontrolled cellular proliferation (Figure 6). The gene discussed is ULK3; the disease is familial pancreatic carcinoma.