We also found the total numbers of sole activators of FOXM1 [58], PDGFRA [59], OPN [60], CYCLIN_D [61], [62], CYCLIN_E [63], BMI [64], SNAI1 [65], JAGGED2 [66], SFRP [67] were increased in Glioma scenario as compared to the canonical HH pathway. This evidence concerns the gene SPP1 and central nervous system cancer.