In sharp contrast with leprosy, where susceptibility to the disease is associated with haplotypes generating high MBL levels [35] and low MASP-2 levels (this study), low MBL levels generated by the MBL2*LYQC haplotype increase susceptibility to malaria [16], [40]–[42], whereas low MASP-2 levels generated by the p.439H variant are protective [16]. This evidence concerns the gene MASP2 and malaria.