CFTR and vibrio infectious disease: Given the inhibitory role of AMPK on CFTR, we hypothesized that AMPK can be utilized as a pharmacological target to negate the hypersecretion of chloride that occurs not only in the course of cholera, but also during many other enterotoxigenic diarrhea entities, such as enterotoxigenic E.coli mediated diarrhea (Figure 1).