Beclin-1 was positively expressed in 42.7% (35/82) of the hypopharyngeal squamous cell carcinoma specimens, which was markedly lower than that of adjacent non-cancerous tissues (79.6%, 43/54) (P<0.0001) (Figure 1A and 1B and Table 2). The gene discussed is BECN1; the disease is hypopharynx squamous cell carcinoma.