PDPK1 is also involved in glucose metabolism and a body of still controversial evidence links the switch towards aerobic glycolysis in tumor cells with the upregulation of HIF-1α target genes (e.g.PDPK1, Glut1, Pfk1, Ldha) under the control of the histone deacetylase SIRT6 [31], [32]. This evidence concerns the gene PFKM and neoplasm.