Taking into account previous results from our laboratory [9], [10] and the present ones demonstrating degradation (proteolysis) of sarcomeric actin and myosin, the myocardium of mice 24 hours after severe sepsis was examined under the electron microscope in order to evaluate autophagy/lysosomal degradation as compared with sham-operated controls. The gene discussed is MYH14; the disease is Sepsis.