Interestingly, only 24 month-old Abcc6−/− mice showed cardiac hypertrophy: the HW/BW ratios were 6.6±0.7 mg/g in Abcc6−/− mice group vs. 5.2±0.3 mg/g in WT mice group (p<0.01); and WGA staining revealed a clear increase in the size of cardiomyocytes (Figure 3). The gene discussed is ABCC6; the disease is cardiac hypertrophy.