Screening for cryptococcal disease has not been widely available in RLS, but it has been shown that a positive serum cryptococcal antigen test prior to commencement of ART is highly sensitive for predicting the development of cryptococcal meningitis and that screening those with CD4 <100 cells/μL is a cost effective measure to reduce cryptococcal disease [23], [24]. Here, CD4 is linked to Cryptococcal meningitis.