Although, by day 11, the relative numbers ofCD3+, CD4+ and CD8+ were the same in animals bearing 4T1 or 67NR tumor cells,the absolute numbers of CD4+, but not CD8+ T cells in the BM of 4T1 positivemice were already higher than in the other groups (Figures S2Aand S2B).Since these tumors are derived from BALB/c mice and MMTV positive, we checkedwhether this early increase in CD4 T cell numbers in the BM could be the resultof superantigen stimulation. The gene discussed is CD4; the disease is neoplasm.