Thus, germline mutations in the BRCA2, p16/CDKN2A, STK11, and PRSS1, that are responsible for familial breast cancer, Familial atypical multiple melanoma, Peutz-Jeghers and Familial pancreatitis, respectively, have been clearly associated with an increase risk of pancreatic cancer [4]–[7]. This evidence concerns the gene CDKN2A and pancreatic neoplasm.