PALB2 and Fanconi anemia: Interestingly, the gene underlying the D1 subtype of Fanconi anemia, FANCD1[15], was found to be BRCA2 and biallelic mutations in BRCA2/FANCD1 originate a phenotype with high risk of childhood malignancies, very similar to that produced by PALB2/FANCN biallelic mutations.