BRCA2 and pancreatic neoplasm: Thus, germline mutations in the BRCA2, p16/CDKN2A, STK11, and PRSS1, that are responsible for familial breast cancer, Familial atypical multiple melanoma, Peutz-Jeghers and Familial pancreatitis, respectively, have been clearly associated with an increase risk of pancreatic cancer [4]–[7].