As shown in Figs. 4 and 5, the results demonstrated that IL-8 and ICAM-1 RNA expression was downregulated by APS, at the average levels of 2.227±0.289 and 2.611±1.052 respectively, compared with 6.033±0.808 and 4.880±0.891 in the hyperoxia group. Here, CXCL8 is linked to autoimmune polyendocrinopathy.